• Average baseline weight was 233 pounds (106kg)
  • Average baseline BMI was 38
  • Liraglutide was titrated to a dose of 3 mg daily during a 4-week period
  • All patients received instructions on consuming a 500cal/day deficit diet along with exercise counseling
  • Diabetics were excluded
  • Dropout rate - liraglutide 28%; placebo 35.6%
  • Reference [1,2]
Liraglutide (Lir) vs placebo
in a 56-week weight loss trial
Placebo
(N=1244)
Lir 3 mg daily
(N=2487)
Weight loss (%)
(average % change from baseline at 56 weeks)
-3% -7.4%
Weight loss (pounds)
(average pounds lost at 56 weeks)
7 17

  • Average baseline weight was 238 pounds (108 kg)
  • Average baseline BMI was 39
  • All patients received instructions on consuming a 500 cal/day deficit diet along with exercise counseling
  • All participants were prediabetic (A1C 5.7 - 6.4%)
  • Dropout rate - liraglutide 47%; placebo 55%
  • Reference [4]
Liraglutide (Lir) vs placebo
for 3 years in prediabetics
Placebo
(N=738)
Lir 3 mg daily
(N=1472)
Weight loss (%)
(average % change from baseline at 3 years)
-1.9% -6.1%
Weight loss lbs (kg)
(average pounds lost at 3 years)
4.4 lbs (2 kg) 14.3 lbs (6.5 kg)

  • Average baseline weight was 233 pounds (106kg)
  • Average baseline BMI was 37
  • Liraglutide was titrated by 0.6 mg/week to assigned dose
  • All patients received instructions on exercise and consuming a 500 cal/day deficit diet
  • Dropout rate - liraglutide 3 mg - 23%; liraglutide 1.8 mg - 22%; placebo - 44%
  • Reference [3]
Liraglutide (Lir) vs placebo
for 56 weeks in overweight diabetics
Placebo
(N=212)
Lir 1.8 mg daily
(N=211)
Lir 3 mg daily
(N=423)
Weight loss (%)
(average % change from baseline at 56 weeks)
-2% -4.7% -6%
Weight loss (pounds)
(average pounds lost at 56 weeks)
4.8 11 14




Reference [1]
Side effect Saxenda
(% of patients)
Placebo
(% of patients)
Nausea 39% 14%
Diarrhea 21% 10%
Constipation 19.4% 8.5%
Vomiting 15.7% 3.9%
Upset stomach 9.6% 2.7%
Abdominal pain 5.4% 3.1%
GERD 4.7% 1.7%
Burping 4.5% 0.2%
Flatulence 4% 2.5%













Week Saxenda dose
1 0.6 mg once daily
2 1.2 mg once daily
3 1.8 mg once daily
4 2.4 mg once daily
5 and on 3 mg once daily