THIAZIDE DIURETIC DOSING

All dosing is for ADULTS unless otherwise specified. P = drugs with pediatric dosing recommendations.
References:
PRICING INFO


Drug Dosage form Dosing Generic/Price Food/Other
Chlorothiazide

(Diuril®)
Tablet
  • 250 mg
  • 500 mg
Suspension
  • 250 mg/5 ml
  • Comes in 237 ml bottle
Adults
    Hypertension
    • Starting: 500 - 1000 mg a day
    • Maintenance: 500 - 1500 mg a daily
    • Max: 2000 mg/day
    • May be given in one or two divided doses
    Edema
    • 500 - 1000 mg given 1 - 2 times a day
    • Max: 2000 mg/day

    See precautions for dosing in kidney and liver disease

Pediatric
    Hypertension and diuresis (< 2 years)
    • Dosing: 10 - 20 mg/kg/day (max 375 mg/day)
    • May given once daily or in two divided doses
    • In infants < 6 months of age, doses up to 30 mg/kg/day in two divided doses may be required
    Hypertension and diuresis (2 - 12 years)
    • Dosing: 10 - 20 mg/kg/day (max 1000 mg/day)
    • May given once daily or in two divided doses
TABLET
YES/$

SUSPENSION
NO/$$
FOOD
  • May take without regard to food

OTHER
  • Store suspension at room temperature

Drug Dosage form Dosing Generic/Price Food/Other
Chlorthalidone

(Thalitone®)
Tablet
  • 15 mg
  • 25 mg
  • 50 mg
Adults
    Hypertension
    • Starting: 12.5 - 25 mg once daily
    • Maintenance: 12.5 - 100 mg once daily
    • Max: 100 mg/day
    Edema
    • Starting: 50 - 100 mg once daily or every other day
    • Max: 200 mg/day

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (Child)
    • Starting: 0.3 mg/kg once daily
    • Max: 2 mg/kg (max 50 mg) once daily
    • AAP recommended dosing [2]
YES/$ FOOD
  • Take with food

OTHER
  • In hypertension trials, doses of 12.5 - 25mg a day were typically used
  • In general, a 12.5mg dose of chlorthalidone is equivalent to 25mg of hydrochlorothiazide. See HCTZ vs Chlorthalidone for more.
  • Doses above 50mg/day are rarely used and may lead to significant hypokalemia

Drug Dosage form Dosing Generic/Price Food/Other
Hydrochlorothiazide

(HCTZ)
Tablet
  • 12.5 mg
  • 25 mg
  • 50 mg
Capsule
  • 12.5 mg
Adults
    Hypertension
    • Starting: 25 mg a day (monotherapy)
    • Maintenance: 25 - 50 mg a day
    • Max: 50 mg/day
    • May be given in one or two divided doses
    Edema
    • Maintenance: 25 - 100 mg a day
    • Max: 100 mg/day
    • May be given in one or two divided doses

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension and diuresis (< 2 years)
    • Dosing: 1 - 2 mg/kg/day (max 37.5 mg/day)
    • May given once daily or in two divided doses
    • In infants < 6 months of age, doses up to 3 mg/kg/day in two divided doses may be required
    Hypertension and diuresis (2 - 12 years)
    • Dosing: 1 - 2 mg/kg/day (max 100 mg/day)
    • May given once daily or in two divided doses
YES/$ FOOD
  • May take without regard to food

OTHER
  • A starting dose of 12.5 mg may be appropriate when adding to other medications (ex. ACE inhibitors, ARBs etc.)
  • Doses above 50 mg/day are rarely used

Drug Dosage form Dosing Generic/Price Food/Other
Indapamide
Tablet
  • 1.25 mg
  • 2.5 mg
Hypertension
  • Starting: 1.25 mg once daily
  • Maintenance: 1.25 - 5 mg once daily
  • Max: 5 mg/day
Edema
  • Starting: 2.5 mg once daily
  • Maintenance: 2.5 - 5 mg once daily
  • Max: 5 mg/day

See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Metolazone

(Zaroxolyn®)
Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
Hypertension
  • Typical range: 2.5 - 5 mg once daily
  • Max: 20 mg/day
Edema
  • Typical range: 5 - 20 mg once daily
  • Max: 20 mg/day

See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • May take without regard to food

OTHER

  • COMBINATION PRODUCTS WITH ACE INHIBITORS

Drug Dosage form Dosing Generic/Price Food/Other
Accuretic®
Quinaretic®

Quinapril + HCTZ
Quinapril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension
  • Dosing: 10/12.5 mg - 40/25 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose at intervals of 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Capozide®

Captopril + HCTZ
Captopril - HCTZ
  • 25 mg - 15 mg
  • 25 mg - 25 mg
  • 50 mg - 15 mg
  • 50 mg - 25 mg
Hypertension
  • Dosing: HCTZ 25 - 50 mg/day; Captopril 25 - 150 mg/day
  • May be given once daily or in divided doses
YES/$ FOOD
  • Take one hour before meals

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Lotensin HCT®

Benazepril + HCTZ
Benazepril - HCTZ
  • 5 mg - 6.25 mg
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension
  • Starting: 10/12.5 mg once daily
  • Maintenance: 5/6.25 - 20/25 mg once daily
  • Max: 20/25 mg once daily
  • Increase dose at intervals of every 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Monopril HCT®

Fosinopril + HCTZ
Fosinopril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
Hypertension
  • Dosing: HCTZ 12.5 - 50 mg once daily; Fosinopril 10 - 80 mg once daily
  • In trials, the maximum dose used was 40/37.5 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER
  • On average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of HCTZ was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ

Drug Dosage form Dosing Generic/Price Food/Other
Uniretic®

Moexipril + HCTZ
Moexipril - HCTZ
  • 7.5 mg - 12.5 mg
  • 15 mg - 12.5 mg
  • 15 mg - 25 mg
Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; Moexipril 7.5 - 30 mg/day
  • May be given once daily or in divided doses
YES/$ FOOD
  • Take one hour before a meal

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Vaseretic®

Enalapril + HCTZ
Enalapril - HCTZ
  • 5 mg - 12.5 mg
  • 10 mg - 25 mg
Hypertension
  • Starting: 10/25 mg/day given once daily or in two divided doses
  • Max: 20/50 mg/day
  • Increase dose at intervals of 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Zestoretic®
Prinzide®

Lisinopril + HCTZ
Lisinopril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension/Hyperlipidemia
  • Dosing: HCTZ 6.25 - 50 mg/day; Lisinopril 10 - 80 mg/day
  • Typically dosed once daily
  • Increase dose at intervals or 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

  • COMBINATION PRODUCTS WITH ARBs

Drug Dosage form Dosing Generic/Price Food/Other
Atacand HCT®

Candesartan + HCTZ
Candesartan - HCTZ
  • 16 mg - 12.5 mg
  • 32 mg - 12.5 mg
  • 32 mg - 25 mg
Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; candesartan 8 - 32 mg/day
  • May be given once daily or divided into two doses
YES/$$ FOOD
  • May take without regard to food

OTHER
  • Maximal effect seen within 4 weeks

Drug Dosage form Dosing Generic/Price Food/Other
Avalide®

Irbesartan + HCTZ
Irbesartan - HCTZ
  • 150 mg - 12.5 mg
  • 300 mg - 12.5 mg
Hypertension
  • Starting: 150/12.5 mg once daily
  • Max: 300/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Benicar HCT®

Olmesartan + HCTZ
Olmesartan - HCTZ
  • 20 mg - 12.5 mg
  • 40 mg - 12.5 mg
  • 40 mg - 25 mg
Hypertension
  • Starting: 20/12.5 - 40/12.5 mg once daily
  • Max: 40/25 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Diovan HCT®

Valsartan + HCTZ
Valsartan - HCTZ
  • 80 mg - 12.5 mg
  • 160 mg - 12.5 mg
  • 160 mg - 25 mg
  • 320 mg - 12.5 mg
  • 320 mg - 25 mg
Hypertension
  • Starting: 160/12.5 mg once daily
  • Max: 320/25 mg once daily
  • Titrate dose at intervals of 1 - 2 weeks
YES/$ FOOD
  • May take without regard to food

OTHER
  • Maximum effect seen within 2 - 4 weeks

Drug Dosage form Dosing Generic/Price Food/Other
Hyzaar®

Losartan + HCTZ
Losartan - HCTZ
  • 50 mg - 12.5 mg
  • 100 mg - 12.5 mg
  • 100 mg - 25 mg
Hypertension
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
  • Increase dose at intervals of 3 weeks
Hypertension with LVH to reduce the risk of stroke
  • Starting: 50/12.5 mg once daily
  • Max: 100/25 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Micardis HCT®

Telmisartan + HCTZ
Telmisartan - HCTZ
  • 40 mg - 12.5 mg
  • 80 mg - 12.5 mg
  • 80 mg - 25 mg
Hypertension
  • Starting: 80/12.5 mg once daily
  • Max: 160/25 mg once daily
  • Titrate dose at intervals of 2 - 4 weeks
YES/$$ FOOD
  • May take without regard to food

OTHER
  • Do not remove from blister pack until ready to take

  • COMBINATION PRODUCTS WITH BETA BLOCKERS

Drug Dosage form Dosing Generic/Price Food/Other
Corzide®

Nadolol + Bendroflumethiazide
Nadolol - Bendroflumethiazide
  • 40 mg - 5 mg
  • 80 mg - 5 mg
Hypertension
  • Starting: 40/5 mg once daily
  • Maintenance: 40/5 - 80/5 mg once daily
YES/$$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Dutoprol®

Metoprolol succinate extended-release + HCTZ
Metoprolol - HCTZ
  • 25 mg - 12.5 mg
  • 50 mg - 12.5 mg
  • 100 mg - 12.5 mg
Hypertension
  • Starting: 25 mg/12.5 mg once daily
  • Maintenance: 25 mg/12.5 mg - 200 mg/25 mg once daily
  • Max: 200 mg/25 mg once daily
  • Increase dose at intervals of 2 weeks
NO/$$$$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Inderide®

Propranolol
standard-release + HCTZ
Propranolol - HCTZ
  • 40 mg - 25 mg
  • 80 mg - 25 mg
Hypertension
  • Starting: 40 mg/25 mg twice a day
  • Maintenance: 40 mg/25 mg - 80 mg/25 mg twice a day
  • Max: 80 mg/25 mg twice a day
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Lopressor HCT®

Metoprolol tartrate standard-release + HCTZ
Metoprolol - HCTZ
  • 50 mg - 25 mg
  • 100 mg - 25 mg
  • 100 mg - 50 mg
Hypertension
  • Dosing: Metoprolol may be dosed up to 200 mg a day. HCTZ may be dosed up to 50 mg a day. Daily dose may be given once daily or divided and given twice a day.
  • Metoprolol doses of ≤ 100 mg/day may be more effective if given in divided doses
YES/$ FOOD
  • Take with or immediately following a meal

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Tenoretic®

Atenolol + chlorthalidone
Atenolol - Chlorthalidone
  • 50 mg - 25 mg
  • 100 mg - 25 mg
Hypertension
  • Starting: 50 mg/25 mg once daily
  • Maintenance: 50 mg/25 mg - 100 mg/25 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Ziac®

Bisoprolol + HCTZ
Bisoprolol - HCTZ
  • 2.5 mg - 6.25 mg
  • 5 mg - 6.25 mg
  • 10 mg - 6.25 mg
Hypertension
  • Starting: 2.5 mg/6.25 mg once daily
  • Maintenance: 2.5 mg/6.25 mg - 20 mg/12.5 mg once daily
  • Max: 20 mg/12.5 mg once daily
  • Titrate dose at intervals of 14 days
YES/$ FOOD
  • May take without regard to food

OTHER

  • COMBINATION PRODUCTS WITH OTHER DIURETICS

Drug Dosage form Dosing Generic/Price Food/Other
Maxzide®

HCTZ + Triamterene
HCTZ - Triamterene
  • 25 mg - 37.5 mg
  • 50 mg - 75 mg
Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER
  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure

Drug Dosage form Dosing Generic/Price Food/Other
Dyazide®

HCTZ + Triamterene
HCTZ - Triamterene
  • 25 mg - 37.5 mg
Hypertension or Edema
  • Dosing: 25/37.5 - 50/75 mg once daily
  • Max: 50/75 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER
  • Triamterene helps prevent potassium loss from HCTZ but has no significant effect on blood pressure

Drug Dosage form Dosing Generic/Price Food/Other
Aldactazide®

HCTZ + Spironolactone
HCTZ - Spironolactone
  • 25 mg - 25 mg
  • 50 mg - 50 mg
Hypertension
  • Dosing: 25/25 mg - 100/100 mg/day
  • May be given once daily or in divided doses
Edema
  • Dosing: 25/25 mg - 200/200 mg/day
  • May be given once daily or in divided doses
25/25 mg dose
YES/$

50/50 mg dose
NO/$$$
FOOD
  • Food may increase the absorption of spironolactone. Manufacturer makes no specific recommendation.

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
HCTZ + Amiloride
Amiloride - HCTZ
  • 5 mg - 50 mg
Hypertension or Edema
  • Dosing: 5/50 mg - 10/100 mg/day
  • May be given once daily or in divided doses
YES/$ FOOD
  • Take with food

OTHER
  • Amiloride helps prevent potassium loss from HCTZ but has no significant effect on blood pressure

  • OTHER COMBINATION PRODUCTS

Drug Dosage form Dosing Generic/Price Food/Other
Aldoril®

Methyldopa + HCTZ
Methyldopa - HCTZ
  • 250 mg - 15 mg
  • 250 mg - 25 mg
Hypertension
  • Starting: 250/15 mg two to three times a day OR 250/25 mg twice a day
  • Max: Methyldopa - 3000 mg/day; HCTZ 50 mg/day
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Clorpres®

Clonidine + Chlorthalidone
Clonidine - Chlorthalidone
  • 0.1 mg - 15 mg
  • 0.2 mg - 15 mg
  • 0.3 mg - 15 mg
Hypertension
  • Dosing: 0.1/15 - 0.6/30 mg/day
  • Max: 0.6/30 mg/day
  • May be given once daily or in 2 divided doses
NO/$$$ FOOD
  • Chlorthalidone should be taken with food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Tekturna HCT®

Aliskiren + HCTZ
Aliskiren - HCTZ
  • 150 mg - 12.5 mg
  • 150 mg - 25 mg
  • 300 mg - 12.5 mg
  • 300 mg - 25 mg
Hypertension
  • Starting: 150/12.5 mg once daily
  • Maintenance: 150/12.5 - 300/25 mg once daily
  • Max: 300/25 mg once daily
  • The antihypertensive effect is largely manifested within 1 week with maximal effect seen within 4 weeks
NO/$$$$ FOOD
  • Patients should establish a routine pattern for taking Tekturna HCT with regard to meals. High-fat meals decrease absorption substantially.

OTHER

  • THREE-DRUG PRODUCTS

Drug Dosage form Dosing Generic/Price Food/Other
Exforge HCT®

Amlodipine + Valsartan + HCTZ
Amlodipine - Valsartan - HCTZ
  • 5 mg - 160 mg - 12.5 mg
  • 5 mg - 160 mg - 25 mg
  • 10 mg - 160 mg - 12.5 mg
  • 10 mg - 160 mg - 25 mg
  • 10 mg - 320 mg - 25 mg
Hypertension
  • Starting: 5/160/12.5 once daily
  • Maintenance: 5/160/12.5 mg - 10/320/25 mg once daily
  • Max: 10/320/25 mg once daily
  • Titrate dose at intervals of 2 weeks
  • Full antihypertensive effect is seen after 2 weeks
YES/$$-$$$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Tribenzor®

Amlodipine + Olmesartan + HCTZ
Amlodipine - Olmesartan - HCTZ
  • 5 mg - 20 mg - 12.5 mg
  • 5 mg - 40 mg - 12.5 mg
  • 5 mg - 40 mg - 25 mg
  • 10 mg - 40 mg - 12.5 mg
  • 10 mg - 40 mg - 25 mg
Hypertension
  • Starting: 5/20/12.5 mg once daily
  • Maintenance: 5/20/12.5 mg - 10/40/25 mg once daily
  • Max: 10/40/25 mg once daily
  • Titrate dose at intervals of 2 weeks
YES/$$-$$$ FOOD
  • May take without regard to food

OTHER