High-intensity statin therapy
(lowers cholesterol by ≥50%)
Moderate-intensity statin therapy
(lowers cholesterol by 30 - 50%)
Low-intensity statin therapy
(lowers cholesterol by < 30%)
  • Atorvastatin (Lipitor®) 40 - 80 mg a day
  • Rosuvastatin (Crestor®) 20 - 40 mg a day
  • Atorvastatin (Lipitor®) 10 - 20 mg a day
  • Rosuvastatin (Crestor®) 5 - 10 mg a day
  • Simvastatin (Zocor®) 20 - 40 mg a day
  • Pravastatin (Pravachol®) 40 - 80 mg a day
  • Lovastatin (Mevacor®) 40 mg a day
  • Fluvastatin XL (Lescol XL®) 80 mg a day
  • Fluvastatin (Lescol®) 40 mg twice a day
  • Pitavastatin (Livalo®) 2 - 4 mg a day
  • Simvastatin (Zocor®) 10 mg a day
  • Pravastatin (Pravachol®) 10 - 20 mg a day
  • Lovastatin (Mevacor®) 20 mg a day
  • Fluvastatin (Lescol®) 20 - 40 mg a day
  • Pitavastatin (Livalo®) 1 mg a day


  • Ranges are from lowest dose of drug to highest
  • Ranges are derived from an average of the studies presented in each manufacturer's package insert
  • At higher doses, some statins have less of an effect on HDL so the "percent increase" may decrease
Medication Total cholesterol LDL HDL
(% increase)
Triglycerides
Pravastatin
(Pravachol®)
28% 34 - 37% 8 - 3% 20%
Fluvastatin
(Lescol®)
17 - 27% 22 - 36% 5 - 8% 15 - 21%
Lovastatin
(Mevacor®)
18 - 32% 26 - 41% 6 - 9% 10 - 23%
Simvastatin
(Zocor®)
28 - 38% 38 - 43% 8 - 12% 19 - 32%
Pitavastatin
(Livalo®)
23 - 31% 31 - 44% 6% 14 - 19%
Atorvastatin
(Lipitor®)
29 - 49% 29 - 51% 8 - 7% 26 - 47%
Rosuvastatin
(Crestor®)
40 - 43% 49 - 54% 11 - 14% 29 - 36%