• 1Considered 2nd and 3rd generation. Norgestimate is converted to norgestrel (half-life 38 hours) and norelgestromin (half-life 18 hours)
  • References [1,9,Package insert]
PROGESTINS GROUPED BY GENERATION
First generation Second generation Third generation
  • Dienogest
  • Ethynodiol Diacetate
  • Norethindrone
  • Norethindrone Acetate
  • Levonorgestrel
  • 1Norgestimate
  • Norgestrel
  • Desogestrel
  • 1Norgestimate
PROGESTINS GROUPED BY STRUCTURE
Testosterone related Progesterone related Spironolactone related
  • Desogestrel (half-life 38 hours)
  • Dienogest (half-life 11 hours)
  • Ethynodiol Diacetate
  • Levonorgestrel (half-life 24-29 hours)
  • Norethindrone (half-life 8-9 hours)
  • Norethindrone Acetate (half-life 7-8 hours)
  • 1Norgestimate
  • Norgestrel (half-life 38 hours)
  • Medroxyprogesterone
  • Megestrol acetate
  • Drospirenone (half-life 30 hours)