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  • Reference [20]
BNP value Heart failure
≤ 100 pg/ml Heart failure unlikely
> 100 pg/ml Heart failure more likely


  • Reference [20]
NT-proBNP value Heart failure
≤ 300 pg/ml Heart failure unlikely
> 300 pg/ml Heart failure more likely

  • Reference [20]
Differences between NT-proBNP and BNP
Half-life Clearance
BNP 22 minutes Endopeptidase
NT-proBNP 60 - 120 minutes Renal


  • Reference [20]
Factors that may affect BNP and NT-proBNP values
Factor Comment
Age
  • BNP and NT-proBNP levels increase naturally with age
Female sex
  • BNP and NT-proBNP levels are higher in females
Kidney disease
  • BNP and NT-proBNP may be elevated in patients with kidney disease
  • Levels begin to rise with CrCl < 60 ml/min
  • NT-proBNP levels may be more sensitive to kidney disease
Diastolic heart failure
  • BNP and NT-proBNP levels may be elevated
    in patients with diastolic heart failure
Acute coronary syndrome
  • BNP and NT-proBNP levels may be elevated in patients with acute
    coronary syndrome even in the absence of heart failure
Pulmonary disease
  • BNP and NT-proBNP levels may be elevated in
    pulmonary diseases including ARDS, severe COPD,
    pulmonary embolism, and primary pulmonary hypertension
Atrial fibrillation
  • BNP and NT-proBNP levels may be elevated in
    atrial fibrillation without heart failure
Obesity
  • BNP and NT-proBNP levels may be lower in obese patients
  • In one study, a BNP of > 54 pg/ml was 90% sensitive
    for heart failure in patients with a BMI ≥ 35
Previous heart failure
  • BNP and NT-proBNP levels may be elevated in patients
    with a history of heart failure who do not have
    acute symptoms of volume overload
High output states
  • BNP and NT-proBNP levels may be elevated in high output
    states (e.g. sepsis, cirrhosis, hyperthyroidism)