INSULIN CHART

PHARMACOKINETICS


NOTE: Pharmacokinetic parameters are affected by age, kidney function, liver function, concomitant medications, medical conditions, and other variables. Because of this, parameters may vary widely among patients.
PRICING INFO

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Afrezza®

(inhaled insulin)
Cartridge
  • 4 unit cartridge of inhalation powder
  • 8 unit cartridge of inhalation powder

Packaged as follows:
  • 60 four unit cartridges
  • 90 four unit cartridges
  • 90 eight unit cartridges
  • 60 four unit and 30 eight unit
  • 30 four unit and 60 eight unit
  • 90 four unit and 90 eight unit
Onset of action
  • 10 - 30 minutes

Duration of action
  • ∼ 2.6 hours

Peak effect
  • ∼ 53 minutes

MIXING
  • Does not apply

DOSING
  • Insulin-naïve patients
    • 4 units with the start of each meal
  • Patients on injectable insulin

OTHER
PACKAGING
  • Afrezza® comes in a sealed foil package with 2 blister cards inside
  • Each blister card has 5 rows of 3 cartridges
  • 3 cartridges are under one blister
  • Before use, cartridge and inhaler should be at room temperature for 10 minutes
  • Inhaler should be thrown away after 15 days

REFRIGERATED
  • Sealed foil package is good until expiration date

ROOM TEMPERATURE
  • Sealed foil package - use within 10 days
  • Sealed blister cards + strips - use within 10 days
  • Opened blister - use within 3 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Apidra®

(insulin glulisine)
Vial (100 units/ml)
  • 10 ml vial

SoloStar® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • SoloStar® is compatible with all BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Apidra® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Apidra® is a premeal (also called prandial) insulin
  • Apidra® should be given within 15 minutes before a meal or within 20 minutes after starting a meal
  • See insulin dosing for more

OTHER
  • Apidra® should be clear and colorless
  • Apidra® is compatible with some insulin pumps
UNPUNCTURED, REFRIGERATED (Vials and Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials and Pens)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Humalog®

(insulin lispro)
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

KwikPen® (200 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

Cartridge (100 units/ml)
  • 3 ml cartridge
  • Comes in package of 5 cartridges
  • For use in HumaPen® Luxura HD and HumaPen® Memoir (see Other for details)

Needles
  • KwikPen® is compatible with all BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Humalog® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humalog® is a premeal (also called prandial) insulin
  • Humalog® should be given within 15 minutes before a meal or immediately after a meal
  • See insulin dosing for more

OTHER
  • Humalog® should be clear and colorless
  • Humalog® is compatible with some insulin pumps
  • HumaPen® Luxura HD is a reusable pen that allows dosing in 0.5 unit increments
  • HumaPen® Memoir records the time, date, and dose of the last 16 injections
UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens, Cartridges)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Novolog®

(insulin aspart)
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

FlexTouch® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses

Cartridge (100 units/ml)
  • 3 ml cartridge
  • for use in NovoPen® reusable pens

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Novolog® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolog® is a premeal (also called prandial) insulin
  • Novolog® should be injected immediately (within 5-10 minutes) before a meal
  • See insulin dosing for more

OTHER
  • Novolog® should be clear and colorless
  • Novolog® is compatible with some insulin pumps
UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens, Cartridges)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Humulin® R

(regular)
Humulin® R U-100
Contains 100 units/ml
  • 10 ml vial

Humulin® R U-500
Contains 500 units/ml
  • 20 ml vial
  • U-500 syringe must be prescribed with vial

Humulin® R U-500 KwikPen®
Contains 500 units/ml
  • 3 ml pen
  • Comes in carton of 2 or 5 pens

Syringes (U-500)
  • Humulin® R U-500 insulin syringe for use with U-500 vial
  • Syringe must be prescribed with U-500 vial
  • Syringe is only for use with U-500 vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • 6 - 8 hours

Peak effect
  • 2 - 3 hours

MIXING
  • Mix with NPH only
  • Draw Humulin® R first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humulin® R is a premeal (also called prandial) insulin
  • Humulin® R should be followed by a meal within approximately 30 minutes of administration
  • See insulin dosing for more

OTHER
  • Humulin® R should be clear and colorless
  • Humulin® R U-500 should only be prescribed to patients who require > 200 units of insulin per day
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 40 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 40 days

UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Novolin® R

(regular)
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • 6 - 8 hours

Peak effect
  • 2 - 3 hours

MIXING
  • Mix with NPH only
  • Draw Novolin® R first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolin® R is a premeal (also called prandial) insulin
  • Novolin® R should generally be injected approximately 30 minutes prior to the start of a meal
  • See insulin dosing for more

OTHER
  • Humulin® R should be clear and colorless
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Humulin® N

(NPH)
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 2 - 4 hours

Duration of action
  • up to 20 hours

Peak effect
  • 4 - 10 hours

MIXING
  • Humulin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Humulin® N after other insulin
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humulin® N is a basal insulin
  • See insulin dosing for more

OTHER
  • Humulin® N should be mixed before use (see instructions with product)
  • Humulin® N should appear uniformly cloudy with no particulate matter after mixing
  • Information on converting between NPH and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 31 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 14 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 31 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 14 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Novolin® N

(NPH)
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 2 - 4 hours

Duration of action
  • up to 20 hours

Peak effect
  • 4 - 10 hours

MIXING
  • Novolin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Novolin® N after other insulin
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolin® N is a basal insulin
  • See insulin dosing for more

OTHER
  • Novolin® N should be mixed before use (see instructions with product)
  • Novolin® N should appear uniformly cloudy with no particulate matter after mixing
  • Information on converting between NPH and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Vials are good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 42 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Basaglar®

(insulin glargine)
Kwikpen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

Needles
  • Compatible with BD® pen needles
Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Basaglar® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily
  • Basaglar® may be administered at any time during the day
  • Basaglar® should be administered at the same time every day
  • Basaglar® is a basal insulin
  • See insulin dosing for more

OTHER
  • Basaglar® should be clear and colorless
  • Information on converting between Basaglar® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Pens are good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Lantus®

(insulin glargine)
Vial (100 units/ml)
  • 10 ml vial

SoloStar® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

Needles
  • Compatible with BD® pen needles
Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Lantus® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily
  • Lantus® may be administered at any time during the day
  • Lantus® should be administered at the same time every day
  • Lantus® is a basal insulin
  • See insulin dosing for more

OTHER
  • Lantus® should be clear and colorless
  • Information on converting between Lantus® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Toujeo®

(insulin glargine)
SoloStar® (300 units/ml)
  • 1.5 ml pen
  • Comes in package of 3 or 5 pens

Needles
  • Compatible with BD® Ultra-Fine pen needles
Onset of action
  • 6 hours

Duration of action
  • 24+ hours
  • Steady state is reached at ≥ 5 days

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Toujeo® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg once daily
  • Toujeo® may be administered at any time during the day
  • Toujeo® should be administered at the same time every day
  • Toujeo® is a basal insulin
  • In a multidose study, the glucose-lowering effect of Toujeo® was about 27% lower than that of an equivalent dose of Lantus®
  • See insulin dosing for more

OTHER
  • Toujeo® should be clear and colorless
  • Information on converting between Toujeo and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 42 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Levemir®

(insulin detemir)
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

FlexTouch® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 1 - 3 hours

Duration of action
  • 6 - 24 hours
  • Levemir's duration of action depends on the dose

Dose (units/kg) Duration (hours)
0.1 6
0.2 12
0.4 20
≥0.8 22 - 24

Peak effect
  • Varies

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Levemir® may be dosed once- or twice-daily
  • Once-daily doses should be administered with the evening meal or at bedtime
  • With twice-daily dosing, the evening dose can be administered with the evening meal, at bedtime, or 12 hours after the morning dose
  • The recommended starting dose of Levemir® in type 2 diabetics is 10 Units (or 0.1-0.2 Units/kg) given once daily in the evening or divided into a twice-daily regimen
  • Levemir® is a basal insulin
  • See insulin dosing for more

OTHER
  • Levemir® should be clear and colorless
  • Information on converting between Levemir® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 42 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 42 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 42 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Tresiba®

(insulin degludec)
FlexTouch®
  • Comes in 2 strengths:
    • U-100 - 100 units/ml
    • U-200 - 200 units/ml
  • Pens contain 3 mls
  • U-100 comes in package of 5 pens
  • U-200 comes in package of 3 pens

Needles
  • Uses NovoFine®, NovoFine® Plus, and NovoTwist® pen needles

Cobination product - Xultophy®
(Liraglutide + insulin degludec)
  • 100 units of insulin and 3.6 mg of liraglutide/ml
  • Comes in 3 ml pens sold in packages of 5
  • Liraglutide is a GLP-1 analog
Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Tresiba is dosed once daily and may be given at any time during the day
  • The recommended starting dose of Tresiba in insulin-naïve type 2 diabetics is 10 units once daily
  • Tresiba is a basal insulin
  • See insulin dosing for more
  • See Xultophy for information on Xultophy dosing

OTHER
  • Tresiba should be clear and colorless
  • Information on converting between Tresiba and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Pens are good for 56 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 56 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Humalog® Mix 75/25

25% insulin lispro/
75% insulin lispro protamine


Humalog® Mix 50/50

50% insulin lispro/
50% insulin lispro protamine
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 1 - 4 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Dosage should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Humalog® Mix should be resuspended before use (see instructions with product)
  • Humalog® Mix should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 10 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 10 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Humulin® 70/30

70% NPH/
30% regular
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 30 - 60 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 3 - 12 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given 30 - 45 minutes before a meal
  • See insulin dosing for more

OTHER
  • Humulin® 70/30 should be resuspended before use (see instructions with product)
  • Humulin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 31 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 10 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 31 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 10 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Novolin® 70/30

70% NPH/
30% regular
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 3 - 12 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given 30 - 45 minutes before a meal
  • See insulin dosing for more

OTHER
  • Novolin® 70/30 should be resuspended before use (see instructions with product)
  • Novolin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Vials are good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Vials are good for 42 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Novolog® Mix 70/30

70% insulin aspart protamine/
30% insulin aspart
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 10 - 30 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 1 - 4 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Novolog® Mix should be resuspended before use (see instructions with product)
  • Novolog® Mix should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 14 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Vials are good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 14 days

Drug Dosage form Pharmacokinetics Mixing/Dosing/Other Storage
Ryzodeg® 70/30

70% insulin degludec/
30% insulin aspart
FlexTouch® (100 units/ml)
  • Pens contain 3 ml
  • Comes in package of 5 pens

Needles
  • Uses NovoFine® and NovoTwist® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 24+ hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • May be given once or twice daily with any main meal
  • A rapid- or short-acting insulin may be given at other meals if needed
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Ryzodeg should be clear and colorless
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 28 days