INSULIN CHART

PHARMACOKINETICS


NOTE: Pharmacokinetic parameters are affected by age, kidney function, liver function, concomitant medications, medical conditions, and other variables. Because of this, parameters may vary widely among patients.
PRICING INFO

  • * For use in HumaPen® Luxura HD and HumaPen® Memoir
  • Reference: Humalog PI
HUMALOG PRODUCT DETAILS
Name Volume Concentration Max dose per injection Package size
U-100 vial 3 ml and 10 ml 100 units/ml N/A 1 vial
U-100 cartridge* 3 ml 100 units/ml N/A 5 cartridges
U-100 KwikPen® 3 ml 100 units/ml 60 units 5 pens
U-100 Junior KwikPen® 3 ml 100 units/ml 30 units 5 pens
U-200 KwikPen® 3 ml 200 units/ml 60 units 2 pens

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Afrezza®

(inhaled insulin)
Cartridge
  • 4 unit cartridge of inhalation powder
  • 8 unit cartridge of inhalation powder

Packaged as follows:
  • 60 four unit cartridges
  • 90 four unit cartridges
  • 90 eight unit cartridges
  • 60 four unit and 30 eight unit
  • 30 four unit and 60 eight unit
  • 90 four unit and 90 eight unit
Onset of action
  • 10 - 30 minutes

Duration of action
  • ∼ 2.6 hours

Peak effect
  • ∼ 53 minutes

MIXING
  • Does not apply

DOSING
  • Insulin-naïve patients
    • 4 units with the start of each meal
  • Patients on injectable insulin

OTHER
PACKAGING
  • Afrezza® comes in a sealed foil package with 2 blister cards inside
  • Each blister card has 5 rows of 3 cartridges
  • 3 cartridges are under one blister
  • Before use, cartridge and inhaler should be at room temperature for 10 minutes
  • Inhaler should be thrown away after 15 days

REFRIGERATED
  • Sealed foil package is good until expiration date

ROOM TEMPERATURE
  • Sealed foil package - use within 10 days
  • Sealed blister cards + strips - use within 10 days
  • Opened blister - use within 3 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Apidra®

(insulin glulisine)
Vial (100 units/ml)
  • 10 ml vial

SoloStar® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • SoloStar® is compatible with all BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Apidra® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Apidra® is a premeal (also called prandial) insulin
  • Apidra® should be given within 15 minutes before a meal or within 20 minutes after starting a meal
  • See insulin dosing for more

OTHER
  • Apidra® should be clear and colorless
  • Apidra® is compatible with some insulin pumps
UNPUNCTURED, REFRIGERATED (Vials and Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials and Pens)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Humalog®

(insulin lispro)

Needles
  • KwikPen® is compatible with all BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Humalog® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humalog® is a premeal (also called prandial) insulin
  • Humalog® should be given within 15 minutes before a meal or immediately after a meal
  • See insulin dosing for more

OTHER
  • Humalog® should be clear and colorless
  • Humalog® is compatible with some insulin pumps
  • HumaPen® Luxura HD is a reusable pen that allows dosing in 0.5 unit increments
  • HumaPen® Memoir records the time, date, and dose of the last 16 injections
UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens, Cartridges)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Novolog®

(insulin aspart)
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

FlexTouch® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses

Cartridge (100 units/ml)
  • 3 ml cartridge
  • for use in NovoPen® reusable pens

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 10 - 30 minutes

Duration of action
  • 3 - 5 hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • Mix with NPH only
  • Draw Novolog® first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolog® is a premeal (also called prandial) insulin
  • Novolog® should be injected immediately (within 5-10 minutes) before a meal
  • See insulin dosing for more

OTHER
  • Novolog® should be clear and colorless
  • Novolog® is compatible with some insulin pumps
UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

PUNCTURED (Pens, Cartridges)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Humulin® R

(regular)
Humulin® R U-100
Contains 100 units/ml
  • 10 ml vial

Humulin® R U-500
Contains 500 units/ml
  • 20 ml vial
  • U-500 syringe must be prescribed with vial

Humulin® R U-500 KwikPen®
Contains 500 units/ml
  • 3 ml pen
  • Comes in carton of 2 or 5 pens

Syringes (U-500)
  • Humulin® R U-500 insulin syringe for use with U-500 vial
  • Syringe must be prescribed with U-500 vial
  • Syringe is only for use with U-500 vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • 6 - 8 hours

Peak effect
  • 2 - 3 hours

MIXING
  • Mix with NPH only
  • Draw Humulin® R first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humulin® R is a premeal (also called prandial) insulin
  • Humulin® R should be followed by a meal within approximately 30 minutes of administration
  • See insulin dosing for more

OTHER
  • Humulin® R should be clear and colorless
  • Humulin® R U-500 should only be prescribed to patients who require > 200 units of insulin per day
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 40 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 40 days

UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Novolin® R

(regular)
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • 6 - 8 hours

Peak effect
  • 2 - 3 hours

MIXING
  • Mix with NPH only
  • Draw Novolin® R first, then NPH
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolin® R is a premeal (also called prandial) insulin
  • Novolin® R should generally be injected approximately 30 minutes prior to the start of a meal
  • See insulin dosing for more

OTHER
  • Humulin® R should be clear and colorless
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerate or room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Humulin® N

(NPH)
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 2 - 4 hours

Duration of action
  • up to 20 hours

Peak effect
  • 4 - 10 hours

MIXING
  • Humulin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Humulin® N after other insulin
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Humulin® N is a basal insulin
  • See insulin dosing for more

OTHER
  • Humulin® N should be mixed before use (see instructions with product)
  • Humulin® N should appear uniformly cloudy with no particulate matter after mixing
  • Information on converting between NPH and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 31 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 14 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 31 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 14 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Novolin® N

(NPH)
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 2 - 4 hours

Duration of action
  • up to 20 hours

Peak effect
  • 4 - 10 hours

MIXING
  • Novolin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog®
  • Draw Novolin® N after other insulin
  • Inject immediately

DOSING
  • Dosage will vary by patient
  • Novolin® N is a basal insulin
  • See insulin dosing for more

OTHER
  • Novolin® N should be mixed before use (see instructions with product)
  • Novolin® N should appear uniformly cloudy with no particulate matter after mixing
  • Information on converting between NPH and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Vials are good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 42 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Basaglar®

(insulin glargine)
Kwikpen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

Needles
  • Compatible with BD® pen needles
Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Basaglar® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily
  • Basaglar® may be administered at any time during the day
  • Basaglar® should be administered at the same time every day
  • Basaglar® is a basal insulin
  • See insulin dosing for more

OTHER
  • Basaglar® should be clear and colorless
  • Information on converting between Basaglar® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Pens are good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form / Studies Pharmacokinetics Mixing / Dosing / Other Storage
Lantus®

(insulin glargine)
Vial (100 units/ml)
  • 10 ml vial

SoloStar® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5 pens

Needles
  • Compatible with BD® pen needles

Studies

Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Lantus® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily
  • Lantus® may be administered at any time during the day
  • Lantus® should be administered at the same time every day
  • Lantus® is a basal insulin
  • See insulin dosing for more

OTHER
  • Lantus® should be clear and colorless
  • Information on converting between Lantus® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Levemir®

(insulin detemir)
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

FlexTouch® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5
  • FlexTouch® pen button maintains the same extension at all doses

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 1 - 3 hours

Duration of action
  • 6 - 24 hours
  • Levemir's duration of action depends on the dose

Dose (units/kg) Duration (hours)
0.1 6
0.2 12
0.4 20
≥0.8 22 - 24

Peak effect
  • Varies

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Levemir® may be dosed once- or twice-daily
  • Once-daily doses should be administered with the evening meal or at bedtime
  • With twice-daily dosing, the evening dose can be administered with the evening meal, at bedtime, or 12 hours after the morning dose
  • The recommended starting dose of Levemir® in type 2 diabetics is 10 Units (or 0.1-0.2 Units/kg) given once daily in the evening or divided into a twice-daily regimen
  • Levemir® is a basal insulin
  • See insulin dosing for more

OTHER
  • Levemir® should be clear and colorless
  • Information on converting between Levemir® and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 42 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 42 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 42 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Toujeo®

(insulin glargine)
SoloStar® (300 units/ml)
  • 1.5 ml pen
  • Comes in package of 3 or 5 pens

Needles
  • Compatible with BD® Ultra-Fine pen needles
Onset of action
  • 6 hours

Duration of action
  • 24+ hours
  • Steady state is reached at ≥ 5 days

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • The recommended starting dose of Toujeo® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg once daily
  • Toujeo® may be administered at any time during the day
  • Toujeo® should be administered at the same time every day
  • Toujeo® is a basal insulin
  • In a multidose study, the glucose-lowering effect of Toujeo® was about 27% lower than that of an equivalent dose of Lantus®
  • See insulin dosing for more

OTHER
  • Toujeo® should be clear and colorless
  • Information on converting between Toujeo and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 42 days

Drug Dosage form / Studies Pharmacokinetics Mixing / Dosing / Other Storage
Tresiba®

(insulin degludec)
FlexTouch®
  • Comes in 2 strengths:
    • U-100 - 100 units/ml
    • U-200 - 200 units/ml
  • Pens contain 3 mls
  • U-100 comes in package of 5 pens
  • U-200 comes in package of 3 pens

Needles
  • Uses NovoFine®, NovoFine® Plus, and NovoTwist® pen needles

Studies

Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Tresiba is dosed once daily and may be given at any time during the day
  • The recommended starting dose of Tresiba in insulin-naïve type 2 diabetics is 10 units once daily
  • Tresiba is a basal insulin
  • See insulin dosing for more
  • See Xultophy for information on Xultophy dosing

OTHER
  • Tresiba should be clear and colorless
  • Information on converting between Tresiba and other insulins - Click here
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Pens are good for 56 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 56 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Humalog® Mix 75/25

25% insulin lispro/
75% insulin lispro protamine


Humalog® Mix 50/50

50% insulin lispro/
50% insulin lispro protamine
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 1 - 4 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Dosage should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Humalog® Mix should be resuspended before use (see instructions with product)
  • Humalog® Mix should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 10 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 10 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Humulin® 70/30

70% NPH/
30% regular
Vial (100 units/ml)
  • 10 ml vial

KwikPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Compatible with BD® pen needles
Onset of action
  • 30 - 60 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 3 - 12 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given 30 - 45 minutes before a meal
  • See insulin dosing for more

OTHER
  • Humulin® 70/30 should be resuspended before use (see instructions with product)
  • Humulin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 31 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 10 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Good for 31 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Keep at room temperature
  • Good for 10 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Novolin® 70/30

70% NPH/
30% regular
Vial (100 units/ml)
  • 10 ml vial
Onset of action
  • 30 - 60 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 3 - 12 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given 30 - 45 minutes before a meal
  • See insulin dosing for more

OTHER
  • Novolin® 70/30 should be resuspended before use (see instructions with product)
  • Novolin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Vials are good for 42 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Vials are good for 42 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Novolog® Mix 70/30

70% insulin aspart protamine/
30% insulin aspart
Vial (100 units/ml)
  • 10 ml vial

FlexPen® (100 units/ml)
  • 3 ml pen
  • Comes in package of 5

Needles
  • Uses NovoFine® and NovoTwist® pen needles
  • BD® Ultra-fine needles are compatible with FlexPen®
Onset of action
  • 10 - 30 minutes

Duration of action
  • up to 20 hours

Peak effect
  • 1 - 4 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Novolog® Mix should be resuspended before use (see instructions with product)
  • Novolog® Mix should appear uniformly cloudy with no particulate matter after resuspending
UNPUNCTURED, REFRIGERATED (Vials, Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Vials)
  • Good for 28 days

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 14 days

PUNCTURED (Vials)
  • Refrigerated or room temp
  • Vials are good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 14 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Ryzodeg® 70/30

70% insulin degludec/
30% insulin aspart
FlexTouch® (100 units/ml)
  • Pens contain 3 ml
  • Comes in package of 5 pens

Needles
  • Uses NovoFine® and NovoTwist® pen needles
Onset of action
  • 10 - 30 minutes

Duration of action
  • 24+ hours

Peak effect
  • 1/2 - 2 hours

MIXING
  • DO NOT MIX with other insulins

DOSING
  • Dosage will vary by patient
  • May be given once or twice daily with any main meal
  • A rapid- or short-acting insulin may be given at other meals if needed
  • Doses should be given within 15 minutes of a meal
  • See insulin dosing for more

OTHER
  • Ryzodeg should be clear and colorless
UNPUNCTURED, REFRIGERATED (Pens)
  • Good until expiration date on product

UNPUNCTURED, ROOM TEMP (Pens)
  • Good for 28 days

PUNCTURED (Pens)
  • Do not refrigerate
  • Pens are good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Soliqua®

insulin glargine + lixisenatide
Pen (100/33)
  • 100 units/ml insulin glargine and 33 mcg/ml lixisenatide
  • Pens contain 3 ml
  • Comes in package of 5 pens
  • Pen window shows units of insulin glargine
NOTE: Parameters are for insulin glargine only

Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak
MIXING
  • DO NOT MIX with other insulins

DOSING
  • Pen is dialed to units of insulin glargine. Minimum dose pen can deliver is 15 units and max is 60 units.
  • If inadequate control on < 30 units of basal insulin or lixisenatide, starting dose is 15 units once daily
  • If inadequate control on 30 - 60 units of basal insulin, starting dose is 30 units once daily
  • Titrate dose up or down by 2 - 4 units every week based on blood sugar goals
  • Max dose is 60 units
  • Administer once a day within the hour prior to the first meal of the day
  • See insulin dosing and GLP-1 analogs for more

OTHER
  • Soliqua should be clear and colorless to almost colorless
UNOPENED / UNUSED PENS
  • Store in refrigerator
  • Good until expiration date on product

AFTER FIRST USE
  • Store at room temperature
  • Good for 28 days

Drug Dosage form Pharmacokinetics Mixing / Dosing / Other Storage
Xultophy®

insulin degludec + liraglutide
Pen (100/3.6)
  • 100 units/ml insulin degludec and 3.6 mg/ml liraglutide
  • Pens contain 3 ml
  • Comes in package of 5 pens
  • Pen window shows units of insulin degludec

Needles
  • Recommended use with NovoFine®, Novofine® Plus or NovoTwist®
NOTE: Parameters are for insulin degludec only

Onset of action
  • 1 - 3 hours

Duration of action
  • 24+ hours

Peak effect
  • No peak
MIXING
  • DO NOT MIX with other insulins

DOSING
  • Pen is dialed to units of insulin degludec. Minimum dose pen can deliver is 10 units and max is 50 units.
  • Recommended starting dose is 16 units once daily
  • Titrate dose up or down by 2 units every 3 - 4 days based on blood sugar goals
  • Max dose is 50 units
  • Administer at the same time each day with or without food
  • Patients who persistently require less than 16 units should discontinue Xultophy and use another product
  • See insulin dosing and GLP-1 analogs for more

OTHER
  • Xultophy should be clear and colorless
UNOPENED / UNUSED PENS
  • Store in refrigerator
  • Good until expiration date on product

AFTER FIRST USE
  • Store at room temperature or in a refrigerator
  • Good for 21 days