• Values are difference from placebo
  • Baseline A1C ∼10.3%; Baseline fasting blood sugar ∼270 mg/dl
  • Reference [1]
Pioglitazone (Pio) monotherapy
26-week placebo-controlled trial
HgA1C
(95% CI)
Fasting blood sugar (mg/dl)
(95% CI)
Pio 15 mg once daily
(N=79)
-1.0%
(-0.4, -1.6)
-39
(-16, -63)
Pio 30 mg once daily
(N=85)
-1.0%
(-0.4, -1.6)
-41
(-18, -64)
Pio 45 mg once daily
(N=76)
-1.6%
(-1.0, -2.2)
-65
(-42, -89)

  • Values are difference from placebo
  • Baseline A1C ∼10%; Baseline FBS ∼258 mg/dl
  • Pio added to patient's standard metformin dose
  • Reference [1]
Pioglitazone (Pio) added to metformin
16-week placebo-controlled trial
Pio 30 mg once daily
(N=161)
HgA1C
(95% CI)
-0.8%
(-0.5, -1.2)
Fasting blood sugar (mg/dl)
(95% CI)
-38
(-26, -49)

  • Values are difference from placebo
  • Baseline A1C ∼8.9%; Baseline FBS ∼227 mg/dl
  • Reference [2]
Rosiglitazone (Ros) monotherapy
26-week placebo-controlled trial
HgA1C Fasting blood sugar (mg/dl)
Ros 4 mg once daily
(N=180)
-0.8% -31
Ros 2 mg twice daily
(N=186)
-0.9% -43
Ros 8 mg once daily
(N=181)
-1.1% -49
Ros 4 mg twice daily
(N=187)
-1.5% -62

  • Values are difference from placebo
  • Baseline A1C ∼8.8%; Baseline FBS ∼218 mg/dl
  • All patients were taking metformin 2500 mg/day
  • Reference [2]
Rosiglitazone (Ros) added to metformin
26-week placebo-controlled trial
Ros 4 mg once daily
(N=116)
Ros 8 mg once daily
(N=110)
HgA1C -1.0% -1.2%
Fasting blood sugar (mg/dl) -40 -53

  • Values are difference from placebo
  • Reference [1]
Pioglitazone (Pio) - weight gain in randomized, placebo-controlled trials
Pio 15 mg once daily Pio 30 mg once daily Pio 45 mg once daily
Monotherapy (16 - 26 weeks) 5 lbs
(2.3kg)
(N=79)
5.3 lbs
(2.4kg)
(N=188)
8.8 lbs
(4.4kg)
(N=79)
Added to metformin (16 to 24 weeks) N/A 5 lbs
(2.3kg)
(N=567)
7 lbs
(3.2kg)
(N=407)

  • Values are difference from placebo
  • Reference [2]
Rosiglitazone (Ros) - weight gain in randomized, placebo-controlled trials
Ros 4 mg a day Ros 8 mg a daily
Monotherapy (26 weeks) 4 lbs
(1.9kg)
(N=436)
8.8 lbs
(4kg)
(N=439)
Added to metformin (26 weeks) 4.8 lbs
(2.2kg)
(N=100)
7.7 lbs
(3.5kg)
(N=184)


  • Values are difference from placebo
  • Reference [1]
Pioglitazone (Pio) - lipid changes in a 26-week randomized, placebo-controlled trial
Pio 15 mg once daily Pio 30 mg once daily Pio 45 mg once daily
Triglycerides (mg/dl) -13.8%
(N=79)
-14.4%
(N=84)
-14.1%
(N=77)
HDL (mg/dl) +6.1%
(N=79)
+4.1%
(N=83)
+11%
(N=77)
LDL (mg/dl) +2.4%
(N=63)
+0.4%
(N=74)
+1.2%
(N=62)

  • Values are difference from placebo
  • Reference [2]
Rosiglitazone (Ros) - lipid changes in a 26-week randomized, placebo-controlled trial
Ros 4 mg a day Ros 8 mg a day
Triglycerides (mg/dl) No significant effect No significant effect
HDL (mg/dl) +3.4%
(N=429)
+6.2%
(N=436)
LDL (mg/dl) +9.3%
(N=400)
+13.8%
(N=374)