• Side effects presented are those that occurred in > 4% of patients or at a difference of ≥ 3% when compared to placebo
  • Reference [2]
Side effect Contrave® 16/180 mg twice a day
(2545 patients)
Placebo
(1515 patients)
Nausea 32.5% 6.7%
Constipation 19.2% 7.2%
Headache 17.6% 10.4%
Vomiting 10.7% 2.9%
Dizziness 9.9% 3.4%
Insomnia 9.2% 5.9%
Dry mouth 8.1% 2.3%
Diarrhea 7.1% 5.2%
Anxiety 4.2% 2.8%
Hot flush 4.2% 1.2%
Fatigue 4.0% 3.4%
Tremor 4.0% 0.7%















Morning dose Evening dose
Week 1 1 tablet None
Week 2 1 tablet 1 tablet
Week 3 2 tablets 1 tablet
Week 4 and on 2 tablets 2 tablets