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APPETITE SUPPRESSANT DOSING



Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Benzphetamine

(Didrex®)
Tablet
  • 50 mg
Weight loss
  • Starting: 25 - 50 mg once daily
  • Maintenance: 25 - 50 mg one to three times a day
  • See precautions for dosing in kidney and liver disease
  • 150 mg a day
Take midmorning YES/$-$$
  • DEA Schedule III
  • Tablets are scored so they may be cut in two
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Diethylpropion
immediate-release

(Tenuate®)
Tablet
  • 25 mg
Weight loss
  • Dosing: 25 mg three times a day
  • A midevening dose may be added to overcome night hunger
  • See precautions for dosing in kidney and liver disease
  • 100 mg a day
Take one hour before meals YES/$
  • DEA Schedule IV
  • Usual starting dose is 25 mg three times a day before meals
  • May take a fourth dose midevening to overcome night hunger
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Diethylpropion
extended-release

(Tenuate Dospan®)
Tablet, extended-release
  • 75 mg
Weight loss
  • Dosing: 75 mg once daily
  • See precautions for dosing in kidney and liver disease
  • 75 mg once daily
Take midmorning YES/$
  • DEA Schedule IV
  • Do not cut, chew, or crush tablet
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phendimetrazine
immediate-release

(Bontril® PDM)
Tablet
  • 35 mg
Weight loss
  • Dosing: 35 mg two to three times a day
  • See precautions for dosing in kidney and liver disease
  • 210 mg a day (2 tablets 3 times a day)
Take one hour before meals YES/$
  • DEA Schedule III
  • In some cases, half a tablet (17.5 mg) per dose may be adequate
  • Tablets are scored so they may be cut in two
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phendimetrazine
extended-release

(Bontril®)
Capsule, extended-release
  • 105 mg
Weight loss
  • Dosing: 105 mg once daily
  • See precautions for dosing in kidney and liver disease
  • 105 mg once daily
Take 30 - 60 minutes before morning meal NO/$
  • DEA Schedule III
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phentermine
immediate-release

(Adipex-P®)
Tablet
  • 37.5 mg
Capsule
  • 15 mg
  • 30 mg
  • 37.5 mg
Weight loss
  • Dosing: 37.5 mg once daily
  • Tablet can be split and given twice a day
  • See precautions for dosing in kidney and liver disease
  • 37.5 mg once daily
May take before breakfast or 1-2 hours after breakfast YES/$
  • DEA Schedule IV
  • For some patients, half tablet (18.75 mg) daily may be adequate
  • In some cases, it may be desirable to give half tablets (18.75 mg) two times a day
  • Tablets are scored so that they may be cut in two
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phentermine
immediate-release

(Lomaira™)
Tablet
  • 8 mg
  • Table is scored so it may be halved
Weight loss
  • Dosing: 1 tablet three times a day 30 minutes before meals
  • Tablet may be halved for 4 mg dose
  • See precautions for dosing in kidney and liver disease
  • 8 mg three times a day
Take 30 minutes before meals YES/$
  • DEA Schedule IV
  • Tablets are scored so that they may be halved
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phentermine
orally-disintegrating
tablet

(Suprenza™)
Tablet, orally-disintegrating
  • 15 mg
  • 30 mg
  • 37.5 mg
Weight loss
  • Dosing: 15 - 37.5 mg once daily
  • See precautions for dosing in kidney and liver disease
  • 37.5 mg once daily
May be taken without regard to food NO/$$$
  • DEA Schedule IV
  • Place tablet on tongue where it will dissolve, then swallow with or without water
Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Phentermine
extended-release
resin complex

(Ionamin®)
Capsule
  • 15 mg
  • 30 mg
Weight loss
  • Dosing: 15 - 30 mg once daily
  • See precautions for dosing in kidney and liver disease
  • 30 mg once daily
Take before breakfast or at least 10 - 14 hours before bedtime NO/?
  • DEA Schedule IV
  • Swallow capsules whole. Do not open.




Drug Dosage form Typical dosage range Maximum Dose Food Generic/Price Other
Qsymia®

(Phentermine +
Topiramate)
Capsule
phentermine/topiramate
  • 3.75/23 mg
  • 7.5/46 mg
  • 11.25/69 mg
  • 15/92 mg
Weight loss
  • Starting: 3.75/23 mg once daily for 14 days
  • Maintenance: 7.5/46 mg once daily
  • If appropriate, increase dose after 12 weeks by giving 11.25/69 mg for 14 days, then 15/92 mg once daily
  • 15/92 mg once daily
May be taken without regard to food. Take in morning. NO/$$$$
  • DEA Schedule IV
  • Evaluate weight loss after 12 weeks on 7.5/46 mg dose. If patient has not lost ≥ 3% of baseline body weight, discontinue or increase to next highest dose by giving 11.25/69 mg for 14 days, then 15/92 mg once daily.
  • If patients has not lost ≥ 5% of baseline body weight after 12 weeks on 15/92 mg dose, then discontinue
  • When discontinuing 15/92 mg dose, take every other day for 1 week to avoid precipitating seizure
  • 3.75/23 mg and 11.25/69 mg doses are for titration purposes only
  • Providers and pharmacies must register in the Qsymia REMS program in order to prescribe



  • PRICING

    • $ = 0 - $50
    • $$ = $51 - $100
    • $$$ = $101 - $150
    • $$$$ = > $151

    • Pricing based on one month of therapy at typical doses
    • Pricing based on survey of GoodRX.com®, HEB®, and Costco®, [accessed 9/2014]
    • Pricing may vary by region and availability



  • References:
  • 1 - Manufacturer's Package Insert for each drug listed