Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Citalopram (Celexa®) |
Citalopram tablet
|
Depression
|
Citalopram YES/$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other / Studies | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Escitalopram (Lexapro®) |
Escitalopram tablet
|
Depression
Generalized anxiety disorder
|
Escitalopram YES/$ |
Other
Studies
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Mechanism of Action | FDA-approved indications | Side Effects | Drug Interactions | Precautions / Contraindications |
---|---|---|---|---|---|---|---|---|---|
Fluoxetine capsule
Fluoxetine tablet
Prozac Weekly®
Sarafem® tablet
Symbyax® capsule Olanzapine(mg):Fluoxetine(mg)
|
Fluoxetine (Prozac®)
Prozac weekly®
Sarafem®
Olanzapine + fluoxetine (Symbyax®)
|
Prozac® YES/$ Prozac weekly™ YES/$$-$$$ Sarafem NO/$$$$ Symbyax™ YES/$$$$ |
|
|
Prozac®
Sarafem®
Symbyax®
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Fluvoxamine (Luvox®) (Luvox® CR) |
Luvox® tablet
Luvox CR® capsule
|
Obsessive compulsive disorder
|
Luvox® YES/$ Luvox® CR YES/$$$-$$$$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Paroxetine (Paxil®) (Paxil CR®) (Brisdelle™) (Pexeva®) |
Paxil® (paroxetine HCL) tablet
Paxil CR® (paroxetine HCL) tablet
Pexeva® (paroxetine mesylate) tablet
Brisdelle™ (paroxetine mesylate)
|
Depression
Obsessive compulsive disorder (OCD)
Panic disorder
Social anxiety disorder
Generalized anxiety disorder
Posttraumatic stress disorder
Premenstrual dysphoric disorder
Vasomotor symptoms associated with menopause
|
Paxil® YES/$ Paxil® CR YES/$$-$$$ Pexeva® NO/$$$$ Brisdelle™ NO/$$$-$$$$ |
All
|
|
Paxil®
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Sertraline (Zoloft®) |
Zoloft®
|
Depression
Obsessive compulsive disorder
Panic disorder,
|
Zoloft® YES/$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Desvenlafaxine Succinate (Pristiq®) Desvenlafaxine (Khedezla™) |
Pristiq® extended-release tablet
Khedezla™ extended-release tablet
|
Depression
|
Pristiq® YES/$$-$$$ Khedezla™ YES/$$$-$$$$ |
Pristiq®, Khedezla™
|
|
|
NOTE: P = % of patients on placebo who reported side effect. Side effects presented here are for 100 mg/day dosing.
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Duloxetine (Cymbalta®) |
Cymbalta® capsule
|
Depression
Generalized anxiety disorder
Diabetic peripheral neuropathy
Fibromyalgia
Chronic musculoskeletal pain
|
Cymbalta® YES/$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Levomilnacipran (Fetzima™) |
Fetzima™ extended-release capsule
Titration pack: 20 mg capsule X 2 40 mg capsule X 26 |
Depression
Dosing in kidney disease
Dosing with strong CYP3A4 inhibitors
|
Fetzima™ NO/$$$$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Venlafaxine (Effexor®) (Effexor XR®) |
Effexor® tablet
Effexor XR® extended-release capsule
Effexor XR® extended-release tablet
|
Depression
Generalized anxiety disorder
Social anxiety disorder
Panic disorder
Migraine prevention (off-label)
Diabetic neuropathy (off-label)
|
Effexor® YES/$ Effexor XR® YES/ capsule - $ tablet - $$-$$$ |
Effexor®
Effexor XR®
Switching brands
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other / Studies | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Bupropion (Wellbutrin®) (Wellbutrin SR®) (Wellbutrin XL®) (Zyban®) (Aplenzin®) (Forfivo XL™) (Contrave®) |
Wellbutrin® tablet
Wellbutrin SR® tablet
Wellbutrin XL® tablet
Forfivo XL™ tablet
Zyban® tablet
Aplenzin® (Bupropion hydrobromide) tablet
Contrave® (naltrexone + bupropion) see Contrave® |
Depression
Seasonal affective disorder
Smoking cessation
Weight loss
|
Wellbutrin® YES/$ Wellbutrin SR® YES/$ Wellbutrin XL® YES/$ Forfivo XL™ NO/$$$$ Aplenzin® NO/$$$$ Zyban® YES/$-$$ |
Other
Studies
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Amitriptyline (Elavil®) |
Amitriptyline tablet
|
Depression
Migraine prevention (off-label)
Diabetic neuropathy (off-label)
|
Amitriptyline YES/$ |
|
|
|
NOTE: Side effect profile not well-defined. Clomipramine is another TCA. It has the
most extensive side effect information available. (see clomipramine for more)
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Clomipramine (Anafranil™) |
Clomipramine capsule
|
Obsessive compulsive disorder
|
Anafranil™ YES/$$$$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Desipramine (Norpramin®) |
Desipramine tablet
|
Depression
|
Desipramine YES/$$-$$$ |
|
|
|
NOTE: Side effect profile not well-defined. Clomipramine is another TCA. It has the
most extensive side effect information available. (see clomipramine for more)
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Imipramine (Tofranil™) (Tofranil-PM™) |
Tofranil™ tablet
Tofranil-PM™ capsule
|
Depression
Childhood enuresis (≥ 6 years old)
|
Tofranil™ YES/$ Tofranil PM™ YES/$$$$ |
|
|
Tofranil™
Tofranil PM™
|
NOTE: Side effect profile not well-defined. Clomipramine is another TCA. It has the
most extensive side effect information available. (see clomipramine for more)
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Nortriptyline (Pamelor™) |
Nortriptyline capsule
|
Depression
Herpes zoster neuralgia (off-label)
|
Pamelor™ YES/$ |
|
|
|
NOTE: Side effect profile not well-defined. Clomipramine is another TCA. It has the
most extensive side effect information available. (see clomipramine for more)
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Trazodone (Desyrel®) (Oleptro™) |
Trazodone tablet
Oleptro® extended-release tablet
|
Depression
Insomnia (off-label)
|
Trazodone YES/$ Oleptro™ NO/$$$ |
Trazodone
Oleptro™
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Vilazodone (Viibryd®) |
Viibryd® tablet
Starter kit: 10 mg X 7 20 mg X 7 40 mg X 16 |
Depression
When taken with CYP3A4 strong inhibitors
When taken with CYP3A4 moderate inhibitors
When taken with CYP3A4 strong inducers
|
Viibryd® NO/$$$$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Mirtazapine (Remeron®) (Remeron Soltab®) |
Remeron® tablet
Remeron Soltab® orally disintegrating tablet
|
Depression
|
Remeron® YES/$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|
Drug | Dosage form | Dosage | Generic/Price | Other | Class/Mechanism of Action | Indications (FDA-approved) |
Side Effects | Drug Interactions | Precautions/ Contraindications |
---|---|---|---|---|---|---|---|---|---|
Vortioxetine (Trintellix®) |
Trintellix® tablet
|
Depression
When taken with CYP2D6 strong inhibitors
CYP2D6 poor metabolizers
When taken with CYP3A4 strong inducers
|
Trintellix® NO/$$$$ |
|
|
|
NOTE: P = % of patients on placebo who reported side effect
|
|
|