ACE INHIBITOR DOSING CHART

All dosing is for ADULTS unless otherwise specified. P = drugs with pediatric dosing recommendations.
References:
PRICING INFO


Drug Dosage form Dosing Generic/Price Food/Other
Benazepril

(Lotensin®)
Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg
Adults
    Hypertension
    • Starting: 10 mg once daily
    • Maintenance: 20 - 40 mg/day
    • Max: 80 mg/day
    • May give in one or two divided doses
    • See precautions for dosing in kidney and liver disease

Pediatric
    Hypertension (≥ 6 years old)
    • Dosing: 0.2 mg/kg once daily
    • Max: 0.6 mg/kg (max 40 mg) once daily
    • See Lotensin PI [sec 2.3] for instructions on compounding a 2 mg/ml suspension
YES/$ FOOD
  • May take without regard to food

OTHER
  • Consider starting dose of 5 mg if adding to diuretic
  • If CrCl < 30 ml/min, then starting dose is 5 mg daily. Maximum dose is 40 mg a day.
  • See Lotensin PI [sec 2.3] for instructions on compounding a 2 mg/ml suspension

Drug Dosage form Dosing Generic/Price Food/Other
Captopril

(Capoten®)
Tablet
  • 12.5 mg
  • 25 mg
  • 50 mg
  • 100 mg
Adults
    Hypertension
    • Starting: 25 mg two to three times a day
    • Maintenance: 25 - 150 mg two to three times a day
    • Max: 450 mg/day
    • Increase dose at 1 - 2 week intervals
    Heart failure
    • Starting: 25 mg three times a day
    • Maintenance dose: 50 - 100 mg three times a day
    • Increase dose at 2 week intervals
    Diabetic nephropathy
    • Maintenance dose: 25 mg three times a day

See precautions for dosing in kidney and liver disease

Pediatric
    Hypertension (infants)
    • Starting: 0.05 mg/kg/dose
    • Max: 6 mg/kg/day
    • May given once daily to 4 times a day
    • AAP recommended dosing [2]
    Hypertension (children)
    • Starting: 0.5 mg/kg/dose
    • Max: 6 mg/kg/day
    • Give in three divided doses
    • AAP recommended dosing [2]
YES/$-$$ FOOD
  • Take 1 hour before meals. Food decreases absorption.

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Enalapril

(Vasotec®)
(Epaned®)
Tablet
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg

Solution (Epaned®)
  • 1 mg/ml
  • Comes in 150 ml bottle
Adults
    Hypertension
    • Starting: 5 mg once daily
    • Maintenance: 10 - 40 mg/day
    • Max: 40 mg/day
    • May be given in one or two divided doses
    Heart Failure
    • Starting: 2.5 mg twice a day
    • Maintenance: 2.5 - 20 mg twice a day
    • Max: 40 mg/day
    • Titrate over a period of a few days or weeks
    Asymptomatic left ventricular dysfunction
    • Starting: 2.5 mg twice a day
    • Target: 10 mg twice a day
    • Titrate as tolerated

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (≥ 1 month)
    • Starting: 0.08 mg/kg (max 5 mg) once daily
    • Max: 0.60 mg/kg/day (max 40 mg)
    • May give once daily or in two divided doses
    • AAP recommended dosing [2]
    • See Vasotec PI for instructions on compounding a 1 mg/ml suspension
TABLET
YES/$

SOLUTION
NO/$$$$
FOOD
  • May take without regard to food

OTHER
  • Consider starting dose of 2.5 mg if adding to a diuretic
  • If CrCl is ≤ 30 ml/min, starting dose is 2.5 mg once daily
  • See Vasotec PI for instructions on compounding a 1 mg/ml suspension

Drug Dosage form Dosing Generic/Price Food/Other
Fosinopril

(Monopril®)
Tablet
  • 10 mg
  • 20 mg
  • 40 mg
Adults
    Hypertension
    • Starting: 10 mg once daily
    • Maintenance: 20 - 40 mg/day
    • Max: 80 mg/day
    • May be given in one or two divided doses
    Heart failure
    • Starting dose: 10 mg once daily
    • Maintenance: 20 - 40 mg once daily
    • Max: 40 mg once daily

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (≥ 6 years)
    • Starting: 0.1 mg/kg (max 5 mg) once daily
    • Max: 40 mg/day
    • AAP recommended dosing [2]
    Hypertension (≥ 50 kg)
    • Starting: 5 mg/day
    • Max: 40 mg/day
    • AAP recommended dosing [2]
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Lisinopril

(Zestril®)
(Prinivil®)
(Qbrelis®)
Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 30 mg
  • 40 mg

Solution (Qbrelis®)
  • 1 mg/ml
  • Comes in 150 ml bottle

Adults
    Hypertension
    • Starting: 10 mg once daily
    • Maintenance: 20 - 40 mg once daily
    • Max: 40 mg once daily
    Heart failure
    • Starting: 5 mg once daily
    • Maintenance: 5 - 40 mg once daily
    • Max: 40 mg once daily

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (≥ 6 years)
    • Starting: 0.07 mg/kg (max 5 mg) once daily
    • Max: 0.61 mg/kg (max 40 mg) once daily
    • See Prinivil PI sec 2.5 for instructions on compounding a 1 mg/ml suspension
TABLET
YES/$

SOLUTION
NO/$$$$
FOOD
  • May take without regard to food

OTHER
  • Lower starting doses may be appropriate in patients taking diuretics
  • CrCl 10 - 30 ml/min - start with half the recommended starting dose
  • CrCl < 10 ml/min - starting dose is 2.5 mg once daily
  • See Prinivil PI sec 2.5 for instructions on compounding a 1 mg/ml suspension

Drug Dosage form Dosing Generic/Price Food/Other
Moexipril

(Univasc®)
Tablet
  • 7.5 mg
  • 15 mg
Hypertension
  • Starting: 7.5 mg once daily
  • Maintenance: 7.5 - 30 mg/day
  • Max: 60 mg/day
  • May give in one or two divided doses
  • See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • Take one hour before meals. Food decreases absorption.

OTHER
  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl ≤ 40 ml/min - starting dose is 3.75 mg once daily. Maximum dose is 15 mg a day.

Drug Dosage form Dosing Generic/Price Food/Other
Perindopril

(Aceon®)
Tablet
  • 2 mg
  • 4 mg
  • 8 mg
Hypertension
  • Starting: 4 mg once daily
  • Maintenance: 4 - 8 mg/day
  • Max: 16 mg/day
  • May give in one or two divided doses
Stable coronary artery disease
  • Starting: 4 mg once daily for 2 weeks
  • Maintenance: 8 mg once daily
  • Elderly patients should be started at 2 mg once daily

See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • May take without regard to food

OTHER
  • Lower starting doses may be appropriate in the elderly and in patients taking diuretics
  • Not recommended if CrCl < 30 ml/min. For lesser degrees of renal impairment, starting dose should be 2 mg and dose should not exceed 8 mg.

Drug Dosage form Dosing Generic/Price Food/Other
Quinapril

(Accupril®)
Tablet
  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg
Adults
    Hypertension
    • Starting: 10 - 20 mg once daily
    • Maintenance: 20 - 80 mg/day
    • Max: 80 mg/day
    • May be given in one or two divided doses
    Heart failure
    • Starting: 5 mg twice a day
    • Maintenance: 10 - 20 mg twice a day
    • Increase dose at 1 week intervals

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (age not specified by AAP)
    • Starting: 5 mg/day
    • Max: 80 mg/day
    • AAP recommended dosing [2]
YES/$ FOOD
  • May take without regard to food

OTHER
  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl 30 - 60 ml/min - starting dose is 5 mg a day
  • CrCl 10 - 30 ml/min - starting dose is 2.5 mg a day
  • CrCl < 10 ml/min - has not been studied

Drug Dosage form Dosing Generic/Price Food/Other
Ramipril

(Altace®)
Tablet and capsule
  • 1.25 mg
  • 2.5 mg
  • 5 mg
  • 10 mg
Adults
    Hypertension
    • Starting: 2.5 mg once daily
    • Maintenance: 2.5 - 20 mg/day
    • Max: 20 mg/day
    • May give in one or two divided doses
    Heart failure
    • Starting: 2.5 mg twice a day
    • Target: 5 mg twice a day
    • Increase dose at 3 weeks intervals

See precautions for dosing in kidney and liver disease
Pediatric
    Hypertension (age not specified by AAP)
    • Starting: 1.6 mg/m2/day
    • Max: 6 mg/m2/day
    • AAP recommended dosing [2]
YES/$ FOOD
  • May take without regard to food

OTHER
  • CrCl < 40 ml/min - starting dose is 1.25 mg once daily. Maximum dose is 5 mg a day.

Drug Dosage form Dosing Generic/Price Food/Other
Trandolapril

(Mavik®)
Tablet
  • 1 mg
  • 2 mg
  • 4 mg
Hypertension
  • Starting (nonblack): 1 mg once daily
  • Starting (black): 2 mg once daily
  • Maintenance: 2 - 4 mg/day
  • Max: 8 mg/day
  • May be given in one or two divided doses
Heart failure
  • Starting: 1 mg once daily
  • Target: 4 mg once daily

See precautions for dosing in kidney and liver disease
YES/$ FOOD
  • May take without regard to food

OTHER
  • Lower starting dose may be appropriate in patients taking diuretics
  • CrCl < 30 ml/min - starting dose is 0.5 mg a day
  • Cirrhosis - starting dose is 0.5 mg a day

  • COMBINATION PRODUCTS WITH HCTZ

Drug Dosage form Dosing Generic/Price Food/Other
Accuretic®
Quinaretic®

(Quinapril + HCTZ)
Quinapril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension
  • Dosing: 10/12.5 mg - 40/25 mg once daily
  • Max: 40/25 mg once daily
  • Increase dose at intervals of 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Capozide®

(Captopril + HCTZ)
Captopril - HCTZ
  • 25 mg - 15 mg
  • 25 mg - 25 mg
  • 50 mg - 15 mg
  • 50 mg - 25 mg
Hypertension
  • Dosing: HCTZ 25 - 50 mg/day; Captopril 25 - 150 mg/day
  • May be given once daily or in divided doses
YES/$ FOOD
  • Take one hour before meals

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Lotensin HCT®

(Benazepril + HCTZ)
Benazepril - HCTZ
  • 5 mg - 6.25 mg
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension
  • Starting: 10/12.5 mg once daily
  • Maintenance: 5/6.25 - 20/25 mg once daily
  • Max: 20/25 mg once daily
  • Increase dose at intervals of every 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Monopril HCT®

(Fosinopril + HCTZ)
Fosinopril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
Hypertension
  • Dosing: HCTZ 12.5 - 50 mg once daily; Fosinopril 10 - 80 mg once daily
  • In trials, the maximum dose used was 40/37.5 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER
  • On average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of HCTZ was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ

Drug Dosage form Dosing Generic/Price Food/Other
Uniretic®

(Moexipril + HCTZ)
Moexipril - HCTZ
  • 7.5 mg - 12.5 mg
  • 15 mg - 12.5 mg
  • 15 mg - 25 mg
Hypertension
  • Dosing: HCTZ 12.5 - 50 mg/day; Moexipril 7.5 - 30 mg/day
  • May be given once daily or in divided doses
YES/$ FOOD
  • Take one hour before a meal

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Vaseretic®

(Enalapril + HCTZ)
Enalapril - HCTZ
  • 5 mg - 12.5 mg
  • 10 mg - 25 mg
Hypertension
  • Starting: 10/25 mg/day given once daily or in two divided doses
  • Max: 20/50 mg/day
  • Increase dose at intervals of 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Zestoretic®
Prinzide®

(Lisinopril + HCTZ)
Lisinopril - HCTZ
  • 10 mg - 12.5 mg
  • 20 mg - 12.5 mg
  • 20 mg - 25 mg
Hypertension/Hyperlipidemia
  • Dosing: HCTZ 6.25 - 50 mg/day; Lisinopril 10 - 80 mg/day
  • Typically dosed once daily
  • Increase dose at intervals or 2 - 3 weeks
YES/$ FOOD
  • May take without regard to food

OTHER

  • COMBINATION PRODUCTS WITH CCBs

Drug Dosage form Dosing Generic/Price Food/Other
Lotrel®

amlodipine + benazepril
Amlodipine - Benazepril
  • 2.5 mg - 10 mg
  • 5 mg - 10 mg
  • 5 mg - 20 mg
  • 5 mg - 40 mg
  • 10 mg - 20 mg
Hypertension
  • Starting: 2.5 mg/10 mg once daily
  • Maintenance: 2.5 mg/10 mg - 10 mg/40 mg once daily
  • Max: 10 mg/40 mg once daily
YES/$ FOOD
  • May take without regard to food

OTHER
  • Antihypertensive effect typically seen within 2 weeks

Drug Dosage form Dosing Generic/Price Food/Other
Prestalia®

amlodipine +
perindopril
Perindopril - Amlodipine
  • 3.5 mg - 2.5 mg
  • 7 mg - 5 mg
  • 14 mg - 10 mg
Hypertension
  • Starting: 3.5 mg/2.5 mg once daily
  • Maintenance: 3.5 mg/2.5 mg - 14 mg/10 mg once daily
  • Max: 14 mg/10 mg once daily
  • Increase dose at intervals of 1 to 2 weeks
NO/$$$$ FOOD
  • May take without regard to food

OTHER

Drug Dosage form Dosing Generic/Price Food/Other
Tarka®

extended-release verapamil + trandolapril
Trandolapril - Verapamil ER
  • 2 mg - 180 mg
  • 1 mg - 240 mg
  • 2 mg - 240 mg
  • 4 mg - 240 mg
Hypertension
  • Dosing: Trandolapril is dosed at 1 - 4 mg a day given in one or two divided doses. Verapamil ER is dosed at 120 - 480 mg a day given in one or two divided doses.
  • In trials, Tarka was dosed once daily
YES/$$-$$$ FOOD
  • Take with food

OTHER